Wormpath is a tool to investigate molecular networks in the nematode
Caenorhabditis elegans using information on
genetic interactions provided by the Wormbase. It is
organized as an interactive web service and the results can either be browsed
online or downloaded to a local computer.
This is Wormpath version 1.0.4. The software currently operates on Wormbase Release WS207.
Wormbase - Facilitating insights into nematode biology
Inkscape: Draw Freely
Cytoscape: An Open Source Platform for Complex Network Analysis and Visualization
Frommolt P, Schumacher B (2015): Wormpath: Searching for molecular interaction networks in Caenorhabditis elegans. Source Code Biol Med; 10: 5 [PubMed]
Müller MM, Castells-Roca L, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B (2014): DAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol; 16(12): 1168-79 [PubMed]
Greiss S, Schumacher B, Grandien K, Rothblatt J, Gartner A (2008): Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family. BMC Genomics; 9: 334 [PubMed]
- Sample data
To test the software, please use this list of 419 genes depending on cep-1, the single C. elegans p53 family member, under gamma-ray radiation (Greiss et al., 2008). Experimental evidence for differential gene expression is provided by Fold Change.