Wormpath - Molecular networks in C. elegans

Run a Wormpath analysis   About Wormpath

Input file [Help]
File format [Help]
Evidence [Help]
Interactions to be included [Help]
Iteration depth [Help]
Significance level for networks [Help]




User's Guide, FAQ, People
  • About Wormpath

    Wormpath is a tool to investigate molecular networks in the nematode Caenorhabditis elegans using information on genetic interactions provided by the Wormbase. It is organized as an interactive web service and the results can either be browsed online or downloaded to a local computer.

  • Version

    This is Wormpath version 1.0.4. The software currently operates on Wormbase Release WS207.

  • Weblinks

    Wormbase - Facilitating insights into nematode biology
    Inkscape: Draw Freely
    Cytoscape: An Open Source Platform for Complex Network Analysis and Visualization

  • Publications

    Frommolt P, Schumacher B (2015): Wormpath: Searching for molecular interaction networks in Caenorhabditis elegans. Source Code Biol Med; 10: 5 [PubMed]

    Müller MM, Castells-Roca L, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B (2014): DAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol; 16(12): 1168-79 [PubMed]

    Greiss S, Schumacher B, Grandien K, Rothblatt J, Gartner A (2008): Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family. BMC Genomics; 9: 334 [PubMed]

  • Sample data

    To test the software, please use this list of 419 genes depending on cep-1, the single C. elegans p53 family member, under gamma-ray radiation (Greiss et al., 2008). Experimental evidence for differential gene expression is provided by Fold Change.